Thermo Fisher Scientific PACS2 Polyclonal Antibody
PACS2 단백질을 인식하는 Rabbit Polyclonal 항체로, 인간 시료에 반응합니다. 면역세포화학(ICC/IF)에 사용 가능하며, ER-미토콘드리아 상호작용 연구에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 장기 보관 시 -20°C에서 보관 권장됩니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human PACS2. Recombinant protein control fragment (Product #RP-108130) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2663900 |
Product Specific Information
Immunogen sequence:
TLDVFTERLPP SGRITKTESL VIPSTRSEGK QAGRRGRSTS LKERQAARPQ NERANSLDNE RCPDARSQLQ VQ
Highest antigen sequence identity to the following orthologs:
- Mouse: 89%
- Rat: 90%
Target Information
PACS2 is a multifunctional sorting protein that controls endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In response to apoptotic inducers, PACS2 translocates BID to mitochondria, initiating a cascade involving mitochondrial truncated BID formation, cytochrome c release, and caspase-3 activation, leading to cell death.
PACS2 may also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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