Thermo Fisher Scientific Phospho-CaMKII alpha/beta/delta (Thr305) Polyclonal Antibody
CaMKII alpha/beta/delta의 Thr305 인산화 상태를 특이적으로 검출하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 적합하며 인간, 마우스, 랫트 반응성. 고순도 정제, 액상 형태로 안정적 저장 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CAMK2A (Accession Q9UQM7), corresponding to amino acid residues around phosphorylated Thr305 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816515 |
Product Specific Information
This antibody detects endogenous levels of CaMKII alpha/beta/delta only when phosphorylated at Threonine 305.
Target Information
The Ca²⁺/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases, including CaMKI, CaMKII, and CaMKIV.
CaMKII is a ubiquitously expressed serine/threonine protein kinase activated by Ca²⁺ and calmodulin (CaM), implicated in regulation of cell cycle and transcription.
There are four CaMKII isozymes (alpha, beta, gamma, delta), which may be co-expressed in the same tissue type.
CaMKII alpha is autophosphorylated on Thr286 upon Ca²⁺/CaM complex binding to its autoinhibitory domain — a process known as Ca²⁺/CaM trapping, thought to play a role in synaptic encoding of information.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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