Thermo Fisher Scientific ITPR2 Polyclonal Antibody
Thermo Fisher Scientific의 ITPR2 Polyclonal Antibody는 인간, 마우스, 랫트 반응성을 가진 Rabbit IgG 폴리클로날 항체로, Western blot, IHC, ELISA, IP에 적합합니다. 합성 펩타이드(aa 100-150)를 면역원으로 사용하며, 고순도 친화 크로마토그래피로 정제되었습니다.
- 카탈로그번호
- ITPR2-201AP
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 100–150 on rat Inositol 1,4,5-triphosphate receptor type 2 (IP3R2) protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Inositol 1,4,5-trisphosphate (IP3) is a second messenger for various growth factors, hormones, and neurotransmitters. Upon binding to IP3 receptor (IP3R), IP3 triggers the release of intracellular calcium from luminal stores into the cytosol. The functional IP3R is a homo- or heterotetramer composed of ~240 kDa glycoprotein subunits. IP3R is structurally and functionally related to the ryanodine receptor, another intracellular calcium-release channel. Both receptors can associate with the immunophilin FKBP12 protein, influencing calcium signaling. Phosphorylation of IP3R by PKC enhances IP3-mediated calcium release, while dephosphorylation by calcineurin reduces it, leading to calcium oscillations. Mammalian IP3R subunits arise from three distinct genes (IP3R-I, IP3R-II, IP3R-III) that are differentially expressed across tissues, including heart, liver, kidney, ovary, cerebellum, brain, pancreas, and gastrointestinal tract.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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