Thermo Fisher Scientific ITPR2 Polyclonal Antibody, Biotin
ITPR2 단백질을 인식하는 Biotin-conjugated Rabbit Polyclonal Antibody. Western blot, IHC, ELISA, IP 등 다양한 응용에 적합. 인산화 조절 및 칼슘 신호 연구용. -20°C 보관, 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 100–150 on rat Inositol 1,4,5-triphosphate receptor type 2 (IP3R2) protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA and 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Inositol 1,4,5-trisphosphate (IP3) acts as a second messenger for various growth factors, hormones, and neurotransmitters. Upon binding to IP3R, it triggers the release of intracellular calcium from the lumen to the cytosol. Functional IP3R forms homo- or heterotetramers of approximately 240 kDa glycoprotein subunits. IP3R is structurally and functionally related to the ryanodine receptor, sharing physiological interactions with the immunophilin protein FKBP12.
Phosphorylation of IP3R by PKC enhances IP3-mediated calcium release, while dephosphorylation by calcineurin reduces it, resulting in calcium oscillations. Mammalian IP3R subunits are encoded by three distinct genes with differential expression:
- IP3R-I: heart, liver, kidney, ovary, cerebellar Purkinje neurons
- IP3R-II: predominantly in the brain
- IP3R-III: pancreatic islets, kidney, gastrointestinal tract
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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