Thermo Fisher Scientific CD180 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• RP105 often migrates at 95–105 kDa in SDS-PAGE, despite its predicted molecular weight.
• Suggested positive control: human spleen tissue lysate.
• PA5-20251 can be used with blocking peptide PEP-0373.

Target Information

CD180 (also known as RP105, Bgp95, LY64) is a type I membrane glycoprotein and a member of the Toll-like receptor (TLR) family.
Unlike other TLRs, CD180 lacks the TIR domain in its cytoplasmic tail. Its expression depends on coexpression with MD-1 and parallels TLR4 expression in antigen-presenting cells.

CD180 regulates LPS recognition and B cell signaling by interacting with the TLR4 complex, thereby modulating microbial ligand binding.
Engagement of CD180 by monoclonal antibodies induces B cell activation, upregulation of CD80/CD86, and cell enlargement.
Structurally, CD180 contains extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail, forming the RP105/MD-1 receptor complex.
Dysfunction of CD180 is associated with Kawasaki disease in children and may contribute to rheumatic disease pathology.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.