Thermo Fisher Scientific PAK2 Polyclonal Antibody
PAK2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 면역조직화학(IHC) 실험에 적합. Human, Mouse, Rat 반응성. 항원 친화 크로마토그래피로 정제된 고순도 액상 항체. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–2 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL | - |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 20 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 14 amino acid peptide from near the amino terminus of human PAK2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2571863 |
Product Specific Information
- Suggested positive control: Jurkat cell lysate
- Compatible blocking peptide: PEP-0390
Target Information
PAK2 (serine/threonine-protein kinase PAK2) is a serine/threonine kinase involved in multiple signaling pathways such as cytoskeleton regulation, cell motility, cell cycle progression, apoptosis, and proliferation.
It acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation occurs through binding of active CDC42 and RAC1, inducing a conformational change and subsequent autophosphorylation on several serine/threonine residues.
Full-length PAK2 promotes cell survival and growth. PAK proteins are key effectors linking Rho GTPases to cytoskeletal reorganization and nuclear signaling, functioning as targets for small GTP-binding proteins Cdc42 and RAC.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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