Thermo Fisher Scientific STAT5 beta Polyclonal Antibody
STAT5 beta 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, ICC/IF, IP 등 다양한 응용에 적합합니다. 고순도 항원 친화 크로마토그래피 정제, 높은 예측 반응성, 안정적인 액상 형태로 연구용에 최적화되어 있습니다.
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Thermo Fisher Scientific STAT5 beta Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the C-terminus region of human STAT5B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.23 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792848 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (100%), Rat (100%), Pig (100%), Bovine (100%).
- Positive Control: 293T, A431, HeLa, HepG2.
- Centrifuge briefly prior to opening the vial.
Target Information
The STAT5 beta protein is a member of the STAT family of transcription factors. Upon cytokine or growth factor stimulation, STAT proteins are phosphorylated by receptor-associated kinases and form homo- or heterodimers that translocate to the nucleus to act as transcription activators.
STAT5 beta mediates signal transduction triggered by ligands such as IL2, IL4, CSF1, and various growth hormones. It is involved in processes including TCR signaling, apoptosis, mammary gland development, and sexual dimorphism of liver gene expression.
Abnormal STAT5 beta signaling has been associated with acute promyelocytic leukemia (APLL) due to gene fusion with RARA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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