Thermo Fisher Scientific VASP Polyclonal Antibody
VASP 단백질을 표적하는 Rabbit Polyclonal 항체로, WB, IHC, ICC, ELISA에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 세포 부착 및 이동 관련 연구에 유용합니다. 고순도 친화 크로마토그래피 정제 및 안정한 PBS/glycerol 저장 용액.
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- PA5120257
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 100–200 of human VASP (NP_003361.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.91 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2913829 |
Product Specific Information
- Positive test controls: A-431, Mouse kidney
- Subcellular localization: Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Filopodium membrane, Focal adhesion, Lamellipodium membrane, Tight junction
Immunogen sequence:
AQFAAGMASA LEALEGGGPP PPPALPTWSV PNGPSPEEVE QQKRQQPGPS EHIERRVSNA GGPPAPPAGG PPPPPGPPPP PGPPPPPGLP PSGVPAAAHG A
Target Information
Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. These proteins contain an EVH1 N-terminal domain that binds E/DFPPPPXD/E motif-containing proteins, targeting them to focal adhesions. The mid-region includes a proline-rich domain interacting with SH3 and WW domain-containing proteins, while the C-terminal EVH2 domain mediates tetramerization and binds both G and F actin.
VASP is implicated in filamentous actin formation, cell adhesion, and motility, and may participate in intracellular signaling regulating integrin–extracellular matrix interactions. It is regulated by cyclic nucleotide-dependent kinases PKA and PKG.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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