Thermo Fisher Scientific PUMA alpha Polyclonal Antibody
Thermo Fisher Scientific의 PUMA alpha Polyclonal Antibody는 인간 PUMA α 단백질을 인식하는 Rabbit IgG 항체입니다. Western blot 및 IHC(P)에서 검증되었으며, p53 관련 세포사멸 연구에 적합합니다. 액상 형태로 제공되며, 단기 4°C, 장기 -20°C 보관이 권장됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2–4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide ARARQEGSSPEPVEG corresponding to the N-terminus of human PUMA alpha (aa 2–16) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2064548 |
Product Specific Information
- Predicted to react with mouse based on sequence homology.
- Heat-mediated antigen retrieval using sodium citrate buffer (pH 6.0) is recommended for paraffin section staining.
- Suggested positive control: human breast carcinoma.
- Detects a band at ~23 kDa in K562 cell lysate (Western blot).
- Recognizes the p53-upregulated modulator of apoptosis (PUMA), also known as Bcl-2 binding component 3, JFY-1, or Bcl-2.
Target Information
PUMA is a pro-apoptotic Bcl-2 family member, along with Bax and Noxa, which are transcriptional targets of p53.
The PUMA gene encodes two BH3 domain-containing proteins, PUMA-a and PUMA-b.
PUMA proteins bind Bcl-2, localize to mitochondria, and promote cytochrome c release and apoptosis in response to p53 activation.
Antisense inhibition of PUMA expression reduces p53-mediated apoptosis, indicating its role in the cytochrome c/Apaf-1-dependent pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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