Thermo Fisher Scientific Desmoglein-3 Monoclonal Antibody (DSG3, 1535)
Desmoglein-3 단백질을 인식하는 Mouse monoclonal antibody로, Western blot 및 IHC(P) 실험에 적합합니다. 고순도의 Protein A/G 정제 항체이며, PBS(pH 7.4) 용액에 보존제를 포함하지 않고 제공됩니다. 세포 간 접착 관련 연구 및 pemphigus vulgaris 연구에 활용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | DSG3, 1535 |
| Immunogen | Recombinant human DSG3 extracellular protein fragment |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a member of the desmosomal cadherin family and plays a critical role in cell-cell adhesion.
It is predominantly expressed in stratified squamous epithelium, including the skin, oral mucosa, and esophagus.
Desmoglein 3 has been characterized as the autoantigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease.
Binding of anti-Desmoglein 3 autoantibodies causes loss of cell-cell adhesion, which clinically manifests as blisters on the skin and oral mucosa, and histologically as suprabasilar acantholysis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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