Thermo Fisher Scientific Desmoglein-3 (Squamous Cell Marker) Monoclonal Antibody (5H10)
Desmoglein-3 단백질을 표적하는 마우스 단클론 항체로, 편평상피세포 마커로 사용됩니다. Western blot, ICC/IF, Flow cytometry에 적용 가능하며, 인간 시료에 반응합니다. 고순도 Protein A/G 정제, 액상 형태로 제공되며 -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5H10 |
| Immunogen | Recombinant human DSG3 extracellular protein fragment |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a member of the desmosomal cadherin family and plays a critical role in cell-cell adhesion. It is predominantly expressed in stratified squamous epithelium, including the skin, oral mucosa, and esophagus. Desmoglein 3 has been identified as the autoantigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease. The binding of anti-Desmoglein 3 autoantibodies causes the loss of cell-cell adhesion, leading to blister formation on the skin and oral mucosa, and histologically to suprabasilar acantholysis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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