Thermo Fisher Scientific Desmoglein-3 Monoclonal Antibody (DSG3, 2796)
Desmoglein-3 단백질을 표적으로 하는 Mouse monoclonal 항체로, Western blot과 Peptide Array에 사용 가능. Human 시료에 반응하며 Protein A/G로 정제된 Liquid 형태. 세포 간 접착 연구 및 pemphigus vulgaris 관련 연구에 적합.
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Applications
- Western Blot (WB): 1–2 µg/mL
- Peptide Array (Array): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | DSG3, 2796 |
| Immunogen | Recombinant fragment (around aa 379–491) of human DSG3 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a desmosomal cadherin that plays a crucial role in cell-cell adhesion. It is predominantly expressed in stratified squamous epithelium such as skin, oral mucosa, and esophagus.
Dsg3 is identified as the auto-antigen in pemphigus vulgaris (PV), a severe autoimmune disease. Binding of anti-Dsg3 autoantibodies causes loss of cell-cell adhesion, resulting in blister formation on skin and mucosa and histologically observed as suprabasilar acantholysis.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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