Thermo Fisher Scientific POLI Monoclonal Antibody (OTI5D11), TrueMAB
Human POLI 단백질을 인식하는 마우스 단클론 항체로, Western blot에 최적화됨. Lyophilized 형태로 제공되며 PBS 및 trehalose 버퍼에 보관. DNA 복구 관련 연구에 적합한 고품질 TrueMAB 항체.
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Applications
Tested Dilution
- Western Blot (WB): 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5D11 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 458–740 of human POLI produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Error-prone DNA polymerase involved in DNA repair. Plays a key role in translesion synthesis when normal high-fidelity DNA polymerases stall.
Favors Hoogsteen base-pairing in the active site and inserts the correct base opposite adenosine templates with high fidelity.
Shows low fidelity opposite thymidine templates, preferentially inserting guanosine.
May contribute to hypermutation of immunoglobulin genes.
Forms a Schiff base with 5′-deoxyribose phosphate at abasic sites, but may lack lyase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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