Thermo Fisher Scientific HRX Monoclonal Antibody (4A5A12)
Human KMT2A(HRX) 단백질을 표적으로 하는 Mouse IgG1 단클론 항체. Western blot 및 ELISA에 최적화된 고감도 검출용 항체. Protein G 정제 및 PBS 버퍼에 보관. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4A5A12 |
| Immunogen | Purified recombinant fragment of human KMT2A (aa: 801–956) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898465 |
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
KMT2A is a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, which mediates methylation of Lys-4 of histone H3 (H3K4me) and acetylation of Lys-16 of histone H4 (H4K16ac). Within this complex, KMT2A specifically mediates H3K4me, a marker for epigenetic transcriptional activation. It has weak methyltransferase activity alone and requires other components of the MLL1/MLL complex for full activity. It shows no activity toward histone H3 phosphorylated on Thr-3, less activity toward H3 dimethylated on Arg-8 or Lys-9, and higher activity toward H3 acetylated on Lys-9. KMT2A is required for transcriptional activation of HOXA9 and promotes PPP1R15A-induced apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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