Thermo Fisher Scientific MAPT Monoclonal Antibody (15A4)
MAPT 단백질을 인식하는 Mouse monoclonal antibody(15A4)로, Western blot과 ELISA에 사용 가능. 인간 시료에 반응하며, PBS buffer에 보관. Alzheimer’s disease 연구 등 Tau 단백질 관련 신경퇴행성 질환 연구에 적합.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific MAPT Monoclonal Antibody (15A4)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 15A4 |
| Immunogen | MAPT (NP_058519.2, 167–266 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
TRQPSGTGPE DTEGGRHAPE LLKHQLLGDL HQEGPPLKGA GGKERPGSKE EVDEDRDVDE SSPQDSPPSK ASPAQDGRPP QTAAREATSI PGFPAEGAIP
Target Information
Tau is a neuronal microtubule-associated protein predominantly found on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules, while the N-terminus associates with neural plasma membrane components, suggesting Tau acts as a linker between cytoskeletal and membrane structures.
Axonal polarity is influenced by TAU/MAPT localization within neurons. Short isoforms allow cytoskeletal plasticity, while longer isoforms contribute to stabilization. Hyper-phosphorylated Tau forms paired helical filaments (PHF), the main component of neurofibrillary tangles in Alzheimer’s disease (AD) brains. This modification impairs microtubule binding, leading to neuronal degeneration. Tau phosphorylation is mediated by kinases such as GSK-3β, PKA, cdk5, and casein kinase II. Hyper-phosphorylated Tau is also found in other neurodegenerative disorders including Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.