Thermo Fisher Scientific MAPT Monoclonal Antibody (15A4)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Protein Sequence:
TRQPSGTGPE DTEGGRHAPE LLKHQLLGDL HQEGPPLKGA GGKERPGSKE EVDEDRDVDE SSPQDSPPSK ASPAQDGRPP QTAAREATSI PGFPAEGAIP

Target Information

Tau is a neuronal microtubule-associated protein predominantly found on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules, while the N-terminus associates with neural plasma membrane components, suggesting Tau acts as a linker between cytoskeletal and membrane structures.

Axonal polarity is influenced by TAU/MAPT localization within neurons. Short isoforms allow cytoskeletal plasticity, while longer isoforms contribute to stabilization. Hyper-phosphorylated Tau forms paired helical filaments (PHF), the main component of neurofibrillary tangles in Alzheimer’s disease (AD) brains. This modification impairs microtubule binding, leading to neuronal degeneration. Tau phosphorylation is mediated by kinases such as GSK-3β, PKA, cdk5, and casein kinase II. Hyper-phosphorylated Tau is also found in other neurodegenerative disorders including Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.