Thermo Fisher Scientific ALKBH2 Polyclonal Antibody
인체 및 마우스 ALKBH2 단백질을 검출하는 Thermo Fisher Scientific의 폴리클로날 항체입니다. Western blot에 적합하며, 고순도 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ALKBH2 (Accession Q6NS38), corresponding to amino acid residues I141–A191 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852836 |
Product Specific Information
Antibody detects endogenous levels of total ALKBH2.
Target Information
The E. coli AlkB protein protects against the cytotoxicity of methylating agents by repairing specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 are mammalian homologs of AlkB that catalyze the removal of 1-methyladenine and 3-methylcytosine—modifications that, if left unchecked, could lead to cancerous cells.
Mutations in both ALKBH2 and ALKBH3 have been observed in pediatric brain tumors, indicating that these proteins are important in preventing cancer formation.
Like the histone demethylase JMJD1A, ALKBH2 is a non-heme iron enzyme inhibited by Nickel ions, suggesting that inhibition of ALKBH2 by Nickel ions may play a role in cancer development.
Conversely, ALKBH2 mRNA and protein levels are increased in glioma cells following Photofrin-mediated photodynamic therapy, suggesting that down-regulating ALKBH2 expression may enhance the anti-cancer effectiveness of this treatment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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