Thermo Fisher Scientific CDK8 Polyclonal Antibody
CDK8 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, IP 등 다양한 응용에 적합합니다. 인간 CDK8의 414-464 아미노산 영역을 면역원으로 사용했습니다. 액상 형태로 제공되며, 4°C에서 보관 및 젖은 얼음 상태로 배송됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Item | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 414 and 464 of human cyclin-dependent kinase 8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
- Based on 100% sequence identity, this antibody is predicted to react with Mouse.
Target Information
CDK8 phosphorylates the carboxy-terminal domain of the largest subunit of RNA polymerase II. This protein is coexpressed and copurified with Cyclin C. CDK8 belongs to the cyclin-dependent kinase (CDK) family, which are critical regulators of cell cycle progression. Members such as p34/Cdc2 and Cdk2 function late in the cell cycle, while Cdk4 and Cdk6 are involved in G1 to S progression. Human Cdk8–Cyclin C complex may interact with RNA polymerase, influencing transcription mechanisms related to cell division.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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