Thermo Fisher Scientific MNAT1 Polyclonal Antibody
MNAT1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간·마우스·랫트 반응성 보유. Western blot 검증 완료. 항원 친화 크로마토그래피로 정제된 액상 항체이며, PBS/glycerol 버퍼에 보존. 세포주기 관련 연구용으로 적합.
- 카탈로그번호
- PA549811
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): Tested dilution 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from internal region of human MAT1 (aa 91–140) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635264 |
Product Specific Information
This antibody detects endogenous levels of total MAT1 / MNAT1 protein.
Target Information
Progression through the cell cycle requires activation of cyclin-dependent kinases (Cdks). Cdk2, a key enzyme for cell cycle initiation, is inactive alone and requires cyclin binding and phosphorylation at Thr160 for activation. The enzyme responsible for this activation, Cdk-activating kinase (CAK), consists of a catalytic subunit, a regulatory subunit, and an additional subunit of unknown function. The regulatory subunit, cyclin H, activates Cdk7. Mat1, a protein associated with the cyclin H–Cdk7 complex, is essential for forming an active Cdk–cyclin complex and exhibits kinase activity toward Cdk activation domains and RNA polymerase II. Mat1 represents an assembly factor crucial for active Cdk–cyclin complex formation.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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