Thermo Fisher Scientific HINT1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total HINT1 protein.

Target Information

Histidine triad nucleotide-binding protein 1 (HINT1) is a member of the histidine triad (HIT) protein family, a group of small nucleotide-binding and -hydrolyzing proteins. HINT1 interacts with several diverse proteins and has been suggested to have tumor suppressive activities. It catalyzes the hydrolysis of adenosine 5′-monophosphoramidate substrates such as AMP-morpholidate, although its enzymatic function is not directly linked to tumor suppression. Studies show that HINT1 forms a complex with POSH and JNK in vivo, inhibiting AP-1 activity and c-Jun phosphorylation, contributing to its tumor suppressor role. It has also been proposed as a candidate gene for schizophrenia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.