Thermo Fisher Scientific Estrone Polyclonal Antibody

Applications

Tested Dilution

Publications

ELISA (ELISA)

Assay-dependent

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic oestrone conjugated to BSA.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage conditions

4°C or -20°C if preferred

Shipping conditions

Wet ice

RRID

AB_930768

Product Specific Information

PA1-85741 is specific for oestrone. Less than 0.01% cross-reactivity was observed with oestradiol 17B, oestriol, progesterone and testosterone.

Rabbit anti estrone antibody recognizes the aromatized C18 steroid, estrone.

Target Information

Estrone is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. it is converted from androstenedione directly, or from testosterone via estradiol. In humans, it is produced primarily by the cyclic ovaries, placenta, and the adipose tissue of men and postmenopausal women. Therapeutic estrone is the synthetic form of a naturally occurring estrogen estrone. Estrone diffuses through the cell membrane and binds to and subsequently activates the nuclear estrogen receptor found in the reproductive tract, breast, pituitary, hypothalamus, liver, and bone. The activated hormone-receptor complex gets translocated to the nucleus where it binds to the estrogen response element on the dna and promotes the transcription of target genes involved in the functioning of the female reproductive system and secondary sex characteristics. Estrone increases the hepatic synthesis of sex hormone binding globulin (shbg), thyroid-binding globulin (tbg), and other serum proteins, as well as suppresses the release of follicle-stimulating hormone (fsh) and luteinizing hormone (lh) from the anterior pituitary. [National Center for Biotechnology Information. PubChem Compound Database; CID=5870].

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.