Thermo Fisher Scientific Desmoglein-3 (Squamous Cell Marker) Monoclonal Antibody (DSG3/2837)
Desmoglein-3 단백질을 인식하는 Mouse monoclonal antibody로, 편평상피세포 마커로 사용됩니다. IHC(P), IHC(PFA), Peptide Array에 적합하며, Human 시료 반응성이 검증되었습니다. 단백질 A/G로 정제된 액상 형태로, -20°C에서 보관합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | DSG3/2837 |
| Immunogen | Recombinant fragment (around aa 379–491) of human DSG3 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a member of the desmosomal cadherin family and plays a critical role in cell–cell adhesion. It is predominantly expressed in stratified squamous epithelium, including the skin, oral mucosa, and esophagus.
Desmoglein 3 is the autoantigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease. Binding of anti-Desmoglein 3 autoantibodies causes the loss of cell–cell adhesion, which manifests clinically as blisters on the skin and oral mucosa, and histologically as suprabasilar acantholysis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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