Thermo Fisher Scientific Desmoglein-3 Monoclonal Antibody (DSG3, 2838)
Desmoglein-3 단백질을 표적하는 Mouse IgG1 단일클론 항체로, 인간 시료에 반응합니다. IHC 및 Peptide Array에 사용 가능하며, Protein A/G로 정제된 액상 형태입니다. 세포 간 결합 연구 및 pemphigus vulgaris 관련 연구에 적합합니다.
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Thermo Fisher Scientific Desmoglein-3 Monoclonal Antibody (DSG3, 2838)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | DSG3, 2838 |
| Immunogen | Recombinant fragment (around aa 379–491) human DSG3 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is part of the desmosomal cadherin family and plays a critical role in cell-cell adhesion. It is predominantly expressed in stratified squamous epithelium, including skin, oral mucosa, and esophagus.
Desmoglein 3 is identified as the autoantigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease. Binding of anti-Desmoglein 3 autoantibodies leads to loss of cell-cell adhesion, clinically manifesting as blisters on the skin and oral mucosa, and histologically as suprabasilar acantholysis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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