Thermo Fisher Scientific ADAMTS4 Polyclonal Antibody

Thermo Fisher Scientific ADAMTS4 Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:3,000

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Mouse (94%), Rat (94%), Bovine (94%)
• Positive Control: Mouse brain
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

This gene encodes a member of the ADAMTS protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 motif.
Individual members differ in the number of C-terminal TS motifs, and some have unique C-terminal domains.
The enzyme encoded by this gene lacks a C-terminal TS motif and is responsible for the degradation of aggrecan (a major proteoglycan of cartilage) and brevican (a brain-specific extracellular matrix protein).
These cleavage activities suggest key roles of this enzyme in arthritic disease and central nervous system processes, including potential involvement in glioma progression.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.