Thermo Fisher Scientific PGRP-S Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested dilution: 1:50–1:200

Product Specifications

Product Specific Information

Immunogen sequence:
PMSIGISFMG NYMDRVPTPQ AIRAAQGLLA CGVAQGALRS NYVLKGHRDV QRTLSPGNQL YHLIQN

Target Information

The primary immune recognition is based on structures common among invading pathogens.
Bacterial surface molecules such as lipopolysaccharide (LPS) and peptidoglycan (PGN) are known to elicit immune reactions ranging from cytokine release to fever.

A family of proteins called peptidoglycan recognition proteins (PGRPs) has been identified in mouse and human that binds to peptidoglycans expressed on Gram-positive bacteria.
PGN is an essential cell wall component of virtually all bacteria and serves as an excellent target for recognition by the eukaryotic innate immune system.

The PGRPs (PGRP-L, PGRP-S, PGRP-Ia, and PGRP-Ib) define a new family of human pattern recognition molecules.

• PGRP-L: Primarily expressed in the liver, involved in host defense by producing acute phase proteins and clearing microorganisms from blood.
• PGRP-S: Present in neutrophils, inhibits growth of Gram-positive bacteria, and may function as an antibacterial protein. It is also highly expressed in bone marrow, suggesting additional unidentified functions.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.