Thermo Fisher Scientific RUVBL2 Polyclonal Antibody
RUVBL2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB, IHC, ICC/IF, IP 등 다양한 응용에 적합하며, KLH 결합 합성 펩타이드로 면역화됨. NuA4 복합체 관련 연구 및 DNA 수선, 전사 조절 연구용.
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- PA534608
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Thermo Fisher Scientific RUVBL2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:400 |
| Immunocytochemistry (ICC/IF) | 1 µg/mL |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide conjugated to KLH derived from within residues 300–400 of Human Reptin/TIP49B/RUVB2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551960 |
Product Specific Information
- Heat mediated antigen retrieval recommended prior to tissue staining.
- This antibody is predicted to react with cow and Xenopus laevis based on sequence homology.
Target Information
RUVBL2 possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5′ to 3′) activity.
It is a component of the NuA4 histone acetyltransferase complex, which is involved in transcriptional activation of select genes by acetylation of nucleosomal histones H4 and H2A.
This modification may alter nucleosome–DNA interactions and promote binding with proteins that positively regulate transcription.
The NuA4 complex is implicated in:
- Activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction
- Tumor suppressor mediated growth arrest and replicative senescence
- Apoptosis and DNA repair
RUVBL2 plays an essential role in oncogenic transformation by MYC and modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex.
It may also inhibit the transcriptional activity of ATF2 and participate directly in DNA repair when recruited to sites of DNA damage.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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