Thermo Fisher Scientific TSC2 Polyclonal Antibody
TSC2 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody로, 인간 및 마우스 등 다양한 종에 반응합니다. Western blot에 적합하며 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 -20°C에서 보관합니다.
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Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the carboxy-terminal residues of human tuberin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10979421 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
TSC2 (Tuberin, Tuberous sclerosis complex, TSC Complex Subunit 2) is a tumor suppressor that may function in vesicular transport and regulation of cell growth arrest. It associates with hamartin in a cytosolic complex, possibly acting as a chaperone. Phosphorylation of tuberin on Ser939 and Thr1462 regulates its interaction with hamartin, stimulated by growth factors via the PI3K/Akt pathway. TSC2 also stimulates the intrinsic GTPase activity of RAP1A and RAB5, influencing cellular growth regulation. Mutations in TSC2 are linked to diseases such as lymphangioleiomyomatosis and angiomyolipoma. Alternative splicing produces three isoforms of TSC2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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