Thermo Fisher Scientific Phospho-CHK2 (Ser19) Polyclonal Antibody
Phospho-CHK2 (Ser19) 폴리클로날 항체로 인간 시료에 반응하며, Western blot 및 IHC(P) 분석에 적합. 항원 친화 크로마토그래피로 정제된 비결합형 액상 제품으로, DNA 손상 신호전달 연구에 활용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pSer19 of human Chk2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10981897 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with Chk2 phosphorylated at other sites.
Target Information
CHEK2 (CHK2) is a serine/threonine kinase and a component of the DNA damage checkpoint pathway.
A mutation in CHK2 has been linked to cancer. CHK2 is activated by DNA damage and phosphorylates several modulators of cell cycle control including tumor suppressor proteins.
In addition, Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage.
Chk2 is a putative tumor suppressor protein, with mutations in the Chk2 gene linked to Li-Fraumeni syndrome, a familial cancer associated with inherited TP53 mutations.
Mutations in CHK2 are also thought to confer a predisposition to sarcomas, breast cancer, and brain tumors.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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