Thermo Fisher Scientific Phospho-CHK2 (Thr68) Polyclonal Antibody
Phospho-CHK2 (Thr68) 폴리클로날 항체로, 인간 CHK2 단백질의 인산화 형태를 특이적으로 검출합니다. Western blot, ELISA, IP에 적합하며, 고순도 친화 크로마토그래피 정제 제품입니다. 연구용으로만 사용 가능하며 -20°C에서 보관합니다.
- 카탈로그번호
- 600-401-280
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-CHK2 (Thr68) Polyclonal Antibody
Thermo Fisher Scientific Phospho-CHK2 (Thr68) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1:10,000–1:70,000 |
| Immunoprecipitation (IP) | 1:200–1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to an internal region near aa 50–75 of Human CHK2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate (pH 7.2), 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at -20°C prior to opening.
- Aliquot contents and freeze at -20°C or below for extended storage.
- Avoid repeated freeze/thaw cycles.
- Centrifuge if not clear after standing at room temperature.
- Stable for several weeks at 4°C as undiluted liquid.
- Dilute only prior to immediate use.
This affinity purified antibody is directed against the phosphorylated form of human CHK2 at the pT68 residue. It specifically reacts with phosphorylated CHK2 and shows minimal reactivity with the non-phosphorylated form. No cross-reactivity with CHK2 phosphorylated at other sites.
BLAST analysis suggests reactivity with human and chimpanzee CHK2 (100% homology). Possible cross-reactivity with mouse and rat CHK2 (90% homology). Cross-reactivity with other species has not been determined.
Target Information
CHEK2 (CHK2) is a serine/threonine kinase involved in the DNA damage checkpoint pathway. Mutations in CHK2 are linked to various cancers. CHK2 phosphorylates tumor suppressor proteins including BRCA1, aiding in survival after DNA damage.
Mutations in CHK2 are associated with Li-Fraumeni syndrome and may predispose to sarcomas, breast cancer, and brain tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.