Thermo Fisher Scientific NFkB p52 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Immunogen sequence:
  AGADIHAENE EPLCPLPSPP TSDSDSDSEG PEKDTRSSFR GHTPLDLTCS TKVKTLLLNA AQNTMEPPLT PPSPAGPGLS LGDTALQNLE QLLDGPEAQG SWAELAERLG LRSLVDTYRQ TTSPSGSLLR SYELAGGDLA GLLEALSDMG LEEGVRLLRG PETRDKLPST EVKEDSAYGS QSVEQEAEKL GPPPEPPGGL CHGHPQPQVH
• Positive Samples: Jurkat, MCF7, NCI-H460, Mouse thymus
• Cellular Location: Cytoplasm, Nucleus

Target Information

This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The encoded protein can act as a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, potentially forming fusion proteins. A pseudogene for this gene exists on chromosome 18. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.