Thermo Fisher Scientific MRP1 Polyclonal Antibody
Thermo Fisher Scientific의 MRP1 Polyclonal Antibody는 인간 MRP1/ABCC1 단백질을 인식하는 토끼 유래 IgG 항체입니다. Western blot, ICC/IF, ELISA에 사용 가능하며 고순도 친화 크로마토그래피 정제 제품입니다. 액상 형태로 안정적이며 -20°C에서 보관합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 850–960 of human MRP1/ABCC1 (NP_004987.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.06 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804636 |
Product Specific Information
- Immunogen sequence:
GSYQELLARD GAFAEFLRTY ASTEQEQDAE ENGVTGVSGP GKEAKQMENG MLVTDSAGKQ LQRQLSSSSS YSGDISRHHN STAELQKAEA KKEETWKLME ADKAQTGQVK L - Positive Samples: HepG2
- Cellular Location: Cell membrane, Multi-pass membrane protein
Target Information
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White.
This full transporter belongs to the MRP subfamily, involved in multi-drug resistance. It functions as a multispecific organic anion transporter with substrates including oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin B1. It also transports glucuronides and sulfate conjugates of steroid hormones and bile salts.
Alternative splicing by exon deletion results in several splice variants, maintaining the original open reading frame in all forms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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