Thermo Fisher Scientific Nestin Monoclonal Antibody (NES, 2911)

Thermo Fisher Scientific Nestin Monoclonal Antibody (NES, 2911)

Applications

• Immunohistochemistry (Paraffin) (IHC (P))

Tested Dilution: 1–2 µg/mL

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
• For formalin-fixed tissues: Heat tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, then cool at room temperature for 20 min before staining.

Target Information

Nestin is a Class VI intermediate filament protein abundantly expressed in the developing central nervous system (CNS) and early embryonic neuroepithelial stem cells.
It serves as a key marker for:

• Stem/progenitor cells
• Glioma and tumor endothelial cells
• Angiogenesis evaluation in tumors

Highly specific Nestin antibodies are useful for:

• Characterizing progenitor cell differentiation
• Enhancing therapeutic potential of neural stem/progenitor cells in CNS disease research
• Identifying neuroepithelial tumor cells

Nestin is also expressed in pancreatic hematopoietic stem cell populations and considered a novel angiogenesis marker in proliferating endothelial cells of colorectal cancer tissue.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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