Thermo Fisher Scientific Phospho-CaMKII alpha/beta/delta (Thr305) Polyclonal Antibody
CaMKII alpha/beta/delta 단백질의 Thr305 인산화 부위를 인식하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 사용 가능. 고순도 액상 형태로 제공되며 -20°C에서 보관. 연구용으로 세포 신호전달 및 인산화 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CaMK2 alpha/beta/delta around the phosphorylation site of Thr305 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903085 |
Target Information
The Ca²⁺/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases including CaMKI, CaMKII, and CaMKIV.
CaMKII is an ubiquitously expressed serine/threonine protein kinase activated by Ca²⁺ and calmodulin (CaM), implicated in regulation of the cell cycle and transcription.
There are four CaMKII isozymes—alpha, beta, gamma, and delta—which may or may not be co-expressed in the same tissue type.
CaMKII alpha is autophosphorylated on Thr286 upon binding of the Ca²⁺/CaM complex to its autoinhibitory domain, a process called Ca²⁺/CaM trapping, thought to be involved in synaptic encoding of information.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: PA5-118583_CaMKII_alphabetadelta_Q9UQM7-1_Rabbit.svg)
(이미지: PA5-118583_CaMKII_alphabetadelta_Q13557-1_Rabbit.svg)
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