Thermo Fisher Scientific MLK1 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human MLK1 (MAP3K9). Validated for WB and ICC/IF. Suitable for detecting MAP kinase pathway activity. Supplied as liquid, 1 mg/mL, stored at -20°C. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human MLK1. The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901926 |
Product Specific Information
Centrifuge briefly prior to opening.
Target Information
MAP3K9 (MLK1) is a serine/threonine protein kinase functioning in the MAP kinase pathway. It plays an important role in cellular response cascades triggered by environmental changes. Once activated, it acts as an upstream activator of the MKK/JNK signal transduction cascade through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, which in turn activate JNKs. The MKK/JNK signaling pathway regulates stress responses via activator protein-1 (JUN) and GATA4 transcription factors. MLK1 also participates in the mitochondrial death signaling pathway, including cytochrome c release leading to apoptosis.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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