Thermo Fisher Scientific Phospho-FGFR3 (Tyr577) Polyclonal Antibody
FGFR3 Tyr577 인산화 부위를 특이적으로 인식하는 Rabbit Polyclonal 항체로, WB와 IHC(P)에서 검증됨. 인산화된 FGFR3의 내인성 발현 검출에 적합. 1 mg/mL 액상 형태, PBS/glycerol buffer에 보관. -20°C에서 저장, Wet ice 배송.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human FGFR3 (Accession P22607), corresponding to amino acid residues around phosphorylated Tyr577 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817539 |
Product Specific Information
This antibody detects endogenous levels of FGFR3 only when phosphorylated at Tyr577.
Target Information
FGFR3 is a member of the FGFR family of receptor tyrosine kinases, which regulate various cellular functions such as angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair. Members of this family are implicated in diseases including cancer, rheumatoid arthritis, and diabetic retinopathy. FGFR3 binds fibroblast growth factors and plays a critical role in bone development and maintenance. Mutations in FGFR3 are associated with craniosynostosis and skeletal dysplasia. Three alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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