Thermo Fisher Scientific PRDM2 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:500–1:2,000

ELISA

• Tested Dilution: 1:1,000–1:2,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human PRDM2/KMT8.

Target Information

PRDM2, a member of the nuclear/histone methyltransferase superfamily, contains an N-terminal PR domain, an Rb-binding motif, eight Kruppel-like zinc finger motifs, a nuclear hormone-receptor binding motif, and a C-terminal PR-domain binding motif.
It is ubiquitously expressed at low levels and exists in two isoforms:

• RIZ1 (280 kDa): Contains PR domain
• RIZ2 (250 kDa): Lacks PR domain

PRDM2 acts as a tumor suppressor, playing a key role in cell growth and differentiation. It binds to Retinoblastoma protein, estrogen receptor, GATA-3, and the TPA-responsive element (MTE) of the Heme-oxygenase-1 gene.
It influences the pathogenesis of Retinoblastoma, transcriptional regulation during neuronal differentiation, transactivation of the Heme-oxygenase-1 gene, and serves as a specific effector of estrogen action.
Mutations and hypermethylation can lead to its inactivation in various human cancers, suggesting its potential as a biomarker.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.