Thermo Fisher Scientific CCL19 Monoclonal Antibody (OTI6A3), TrueMAB
인간 CCL19 단백질(아미노산 22-98)에 특이적인 Mouse IgG1 단클론 항체로, Western blot에 최적화됨. 동결건조 형태로 제공되며, PBS 버퍼와 trehalose 포함. 면역세포 이동 및 활성화 연구에 적합한 연구용 시약.
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Thermo Fisher Scientific CCL19 Monoclonal Antibody (OTI6A3), TrueMAB
Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6A3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 22–98 of human CCL19 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
- For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
CCL19, also known as MIP-3 beta (Macrophage Inflammatory Protein 3 beta), is a member of the CC-subfamily of chemokines. It is most closely related to CCL21, sharing 32% amino acid sequence homology.
CCL19 and CCL21 are mainly expressed by stromal cells in T cell-rich zones of lymph nodes and are key mediators of homeostatic trafficking of naive T cells and activated dendritic cells into secondary lymphoid organs.
They also play roles in T cell priming and activation, and lymphocyte recruitment to inflamed tissue.
Both signal via the CCR7 receptor, expressed on T cells and mature dendritic cells. Although both exhibit similar affinity for CCR7, only CCL19 binding leads to receptor desensitization and internalization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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