Thermo Fisher Scientific CCL19 Monoclonal Antibody (OTI6A3), TrueMAB

Thermo Fisher Scientific CCL19 Monoclonal Antibody (OTI6A3), TrueMAB

Applications

• Western Blot (WB)

Tested Dilution: 1:2,000

Product Specifications

Product Specific Information

• For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
• For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

CCL19, also known as MIP-3 beta (Macrophage Inflammatory Protein 3 beta), is a member of the CC-subfamily of chemokines. It is most closely related to CCL21, sharing 32% amino acid sequence homology.
CCL19 and CCL21 are mainly expressed by stromal cells in T cell-rich zones of lymph nodes and are key mediators of homeostatic trafficking of naive T cells and activated dendritic cells into secondary lymphoid organs.
They also play roles in T cell priming and activation, and lymphocyte recruitment to inflamed tissue.
Both signal via the CCR7 receptor, expressed on T cells and mature dendritic cells. Although both exhibit similar affinity for CCR7, only CCL19 binding leads to receptor desensitization and internalization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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