Thermo Fisher Scientific MAGEA3 Chimeric Recombinant Rabbit Monoclonal Antibody (21B4)
MAGEA3 및 MAGEA6에 특이적으로 결합하는 재조합 토끼 단클론 항체로, 다양한 암 연구에 활용 가능. Western blot, IHC, ICC/IF, Flow cytometry, ELISA 등 다양한 어플리케이션에 적합. 고순도의 Protein A 정제 항체로 안정적이며, 장기보관 시 -20°C에서 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
| Flow Cytometry (Flow) | 1 µg/mL |
| ELISA | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 21B4 |
| Immunogen | The original antibody was isolated from a patient suffering from a tumor expressing a tumor specific antigen like MAGE-A3. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody binds human MAGEA3 and MAGEA6, but does not cross-react with other MAGE family members such as MAGE-A1, MAGE-A4, and MAGE-A10.
MAGE-A3 is a tumor-specific antigen expressed in multiple cancers, including melanoma, non-small cell lung cancer, and hematologic malignancies.
Target Information
The MAGEA gene family encodes proteins sharing 50–80% sequence identity.
Promoters and first exons show variability, allowing differential transcriptional regulation.
These genes are clustered at chromosomal location Xq28 and have been implicated in hereditary disorders such as dyskeratosis congenita.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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