Thermo Fisher Scientific IRAK4 Polyclonal Antibody
Western blot, IHC, ICC/IF에 적합한 Rabbit Polyclonal IRAK4 항체. Human IRAK4의 27-288 아미노산 영역 기반 면역원 사용. 다양한 종에 예측 반응성 보유. 0.76 mg/mL 농도의 액상 제품으로 4°C 단기, -20°C 장기 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 27–288 of Human IRAK4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.76 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547174 |
Product Specific Information
- Recommended positive control: U87-MG
- Predicted reactivity: Pig (82%), Sheep (85%), Rhesus Monkey (97%), Bovine (84%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. Overexpression of IRAK-4 activates NF-kappa-B and MAPK pathways. IRAK-4 interacts with and phosphorylates IRAK-1. IRAK-4-deficient animals are completely resistant to challenges with LPS, and both animals and humans lacking IRAK-4 are impaired in their responses to viral and bacterial challenges. Members of the IRAK/Pelle family play a central role in IL-1R/TLR-mediated inflammatory responses and innate immunity.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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