Thermo Fisher Scientific KAP1 (TRIM28) Monoclonal Antibody (OTI9F4)
인간 TRIM28(KAP1)을 표적으로 하는 마우스 단클론 항체로, WB, IHC(P), ICC/IF에 사용 가능. 높은 특이성과 재현성을 제공하며, 액상 형태로 1 mg/mL 농도. 연구용으로만 사용.
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Thermo Fisher Scientific KAP1 (TRIM28) Monoclonal Antibody (OTI9F4)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI9F4 |
| Immunogen | Full length human recombinant protein of human TRIM28 (NP_005753) produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol, 1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The KRAB (Kruppel-associated box) domain is approximately 45 amino acids in length and serves as a transcriptional repression domain found in numerous transcription factors. Over 220 KRAB-zinc finger protein (KRAB-ZFP) genes have been identified in the human genome. These proteins repress transcription through interactions with KAP-1 (KRAB-associated protein 1).
KAP-1 is an 835 amino acid polypeptide containing a RING finger, B boxes, and a PHD finger. It forms complexes with KRAB-domain transcription factors to enhance transcriptional repression efficiency. KAP-1 also interacts directly with HP1 (heterochromatin protein 1) and KRAZ1 (Kruppel-associated box-containing zinc finger protein 1), targeting KRAZ1 to centromeric heterochromatin regions containing HP1α, thereby regulating transcriptional repression. Mutations in KAP-1 that disrupt HP1 binding result in random distribution of KRAZ1 and strong transcriptional activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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