Thermo Fisher Scientific CHMP4B, C Polyclonal Antibody
CHMP4B, C 단백질 인식용 Rabbit Polyclonal Antibody. Western blot 및 IHC에 적합. Human, Mouse, Rat 반응성. 합성 펩타이드 항원 기반으로 제작. 연구용으로만 사용 가능.
- 카탈로그번호
- OSC00061W-100UL
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous (PubMed) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the N-terminal of human CHMP4B, C conjugated to an immunogenic carrier protein. The peptide is homologous in many species including rat, mouse, zebrafish, and xenopus. Specificity: CHMP4B, C. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in many other species including rat, mouse, zebrafish, and xenopus.
Specificity of this antibody: CHMP4B, C.
Target Information
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III), which is involved in multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
MVBs contain intraluminal vesicles (ILVs) generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes for degradation of membrane proteins, lysosomal enzymes, and lipids.
The MVB pathway requires sequential function of ESCRT-0, -I, -II, and -III complexes.
ESCRT-III proteins dissociate from the invaginating membrane before ILV release.
The ESCRT machinery also functions in membrane fission events such as cytokinesis and the budding of enveloped viruses (e.g., HIV-1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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