Thermo Fisher Scientific VPS24 Polyclonal Antibody
VPS24 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 IHC에 적합합니다. Rat, Human, Mouse 반응성이 있으며, 동결건조 형태로 제공됩니다. ESCRT-III 복합체 연구 및 세포 내 단백질 수송 연구에 활용 가능합니다.
- 카탈로그번호
- OSC00060W-100UL
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat, Human, Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the N-terminal of human VPS24 conjugated to an immunogenic carrier protein was used as the antigen. Target family: CHMP3 (UniProt ID: Q9Y3E7-1). |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The antigen is homologous in rat and mouse.
- Specificity: CHMP3.
Target Information
VPS24 (CHMP3) is a probable core component of the endosomal sorting required for transport complex III (ESCRT-III), which is involved in multivesicular body (MVB) formation and sorting of endosomal cargo proteins.
MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes for degradation of membrane proteins such as growth factor receptors, lysosomal enzymes, and lipids.
The ESCRT machinery functions in membrane fission events, including cytokinesis and viral budding (e.g., HIV-1). ESCRT-III proteins likely mediate vesicle extrusion and membrane fission, possibly with the AAA ATPase VPS4.
VPS24 selectively binds to phosphatidylinositol 3,5-bisphosphate [PtdIns(3,5)P2] and PtdIns(3,4)P2. It is involved in late stages of cytokinesis and plays a role in endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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