Thermo Fisher Scientific TRPV4 Polyclonal Antibody
TRPV4 단백질을 인식하는 Sheep 유래 Polyclonal 항체. Western blot 및 IHC에 사용 가능. 생리적 삼투압 변화에 반응하는 TRPV4 채널 연구에 적합. 장기 보관 시 -20°C에서 보관 권장. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:2,000 |
| Immunohistochemistry (IHC) | 1:300–1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the 1st cytoplasmic loop of mouse TRPV4 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2256620 |
Product Specific Information
- Glycerol (1:1) may be added for additional stability.
- Reconstitute with 100 µL of sterile water.
- The peptide is homologous in rat and human.
Target Information
TRPV4 (Transient Receptor Potential Cation Channel Subfamily V Member 4) is a cation-selective channel activated in response to systemic osmotic pressure. It functions as a non-selective calcium-permeant cation channel involved in osmotic sensitivity and mechanosensitivity.
TRPV4 belongs to the OSM9-like transient receptor potential channel (OTRPC) subfamily within the TRP superfamily of ion channels. The TRPV4 protein is thought to regulate systemic osmotic pressure.
Mutations in the TRPV4 gene are associated with spondylometaphyseal and metatropic dysplasia, as well as hereditary motor and sensory neuropathy type IIC. Diseases linked to TRPV4 include Metatropic Dysplasia and Spondylometaphyseal Dysplasia (Kozlowski Type). Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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