Thermo Fisher Scientific ROCK1 Polyclonal Antibody
ROCK1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Human, Mouse, Rat 등 다양한 종에 반응. WB, IHC, ICC/IF, IP 등 다중 응용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태로, 연구용으로 적합.
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Thermo Fisher Scientific ROCK1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 4 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | – |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | View 1 publication |
| Immunoprecipitation (IP) | 1:100–1:500 | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment containing a sequence corresponding to amino acids 107–371 (Q13464) of ROCK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.35 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11155392 |
Product Specific Information
- Recommended positive controls: 293T, A431, HeLa, HepG2, NIH-3T3, C2Cl2, rat brain
- Predicted reactivity: Human (98%), Mouse (98%), Rat (98%), Zebrafish (90%), Rabbit (98%), Chicken (96%), Rhesus Monkey (98%), Bovine (99%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
ROCK1 is a serine/threonine kinase that regulates cell differentiation and migration. The Rho/ROCK pathway is involved in the progression of various human cancers. ROCK1 is a Caspase-3 substrate and contributes to myosin light chain (MLC) activation through direct phosphorylation and inhibition of MLC phosphatase. During apoptosis, ROCK1 is cleaved by caspase-3, removing its inhibitory domain and resulting in constitutive kinase activity, which induces MLC phosphorylation and membrane blebbing.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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