Thermo Fisher Scientific alpha Actinin 4 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive controls: A431, HepG2, NIH-3T3, mouse brain, PC-12
• Predicted reactivity: Mouse (98%), Rat (98%), Zebrafish (89%), Xenopus laevis (93%), Chicken (95%), Rhesus Monkey (100%), Bovine (99%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Alpha actinins belong to the spectrin gene superfamily, a group of cytoskeletal proteins including alpha/beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles:

• In nonmuscle cells, it localizes along microfilament bundles and adherens junctions, linking actin to the membrane.
• In muscle cells, it is found at the Z-disc and dense bodies, anchoring myofibrillar actin filaments.
  This gene encodes a nonmuscle alpha actinin isoform concentrated in the cytoplasm, potentially involved in metastatic processes. Mutations are associated with focal and segmental glomerulosclerosis.

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.