Thermo Fisher Scientific MEI1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human MEI1. Recombinant protein control fragment (Product #RP-95369). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MEI1,uniProtId:Q5TIA1-1,ncbiNodeId:9606,antigenRange:588-670,antigenLength:1274,antigenImageFileName:PA5-61916_MEI1_Q5TIA1-1_Rabbit.svg,antigenImageFileNamePDP:PA5-61916_MEI1_Q5TIA1-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2643864

Product Specific Information

Immunogen sequence: HMKEKFSKKL ASSSFIRLTL ELKARFCSGL SHSALNQVCS NFLYYMCLNL LSAPEKTGPP SKEELSAVSE LLQHGLPQIS SRS

Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 81%.

Target Information

The predominant cause of spermatogenic arrest of meiosis is the failure of homologous chromosomes to accurately synapse. MEI1 (Meiosis inhibitor protein 1), also designated Meiosis defective protein 1, is a 1274 amino acid protein that is likely required for the formation of genetically programmed double-strand breaks, the first step in the initiation of meiosis. With predominant expression in testis, it is likely that defects of the gene encoding MEI1 results in male infertility. Interestingly, studies show that genetic variation in the MEI gene possibly predisposes European Americans but not Israeli men to infertility by meiotic arrest. Human MEI1 shares 79% sequence similarity with its mouse homolog. There are seven isoforms of MEI1 that are produced as a result of alternative splicing events.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.