Thermo Fisher Scientific LYPD6B Polyclonal Antibody

Product Specifications

Product Specific Information

Immunogen sequence:
WAFAKNINFY NVRPPLDPTP FPNSFKCFTC ENAGDNYNCN RWAEDKWCPQ NTQYCLTVHH FTSHGRSTSI TKKCASRSEC HFVGCHHSRD SEHTECRSCC EGMICNVELP TNHTNAVFAV MHAQRTSGSS APTLYLPVLA

Highest antigen sequence identity to orthologs:

• Mouse: 92%
• Rat: 92%

Target Information

Believed to act as a modulator of nicotinic acetylcholine receptor (nAChR) activity.

• Acts on nAChRs in a subtype- and stoichiometry-dependent manner.
• Modulates specifically α3(3):β4(2) nAChRs by enhancing sensitivity to ACh, decreasing maximal current response, and increasing desensitization rate.
• No effect on α7 homomeric nAChRs.
• Modulates α3(2):α5:β4(2) nAChRs in the context of CHRNA5/α5 variant Asn-398 but not its wild-type sequence.
  (Source: UniProt)

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.