Thermo Fisher Scientific MLLT11 Polyclonal Antibody
Human MLLT11 단백질을 인식하는 Rabbit Polyclonal Antibody. WB, IHC, ICC/IF, IP 등 다양한 응용에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 0.2 mg/mL 농도의 액상 형태로 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 1 publication |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
| Immunoprecipitation (IP) | - | View 1 publication |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MLLT11. Recombinant protein control fragment (Product #RP-93690). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789040 |
Product Specific Information
Immunogen sequence:
FWRMPIPELD LSELEGLGLS DTATYKVKDS SVGKMIGQAT AADQEKNPEG DGLLEYSTFN FWRAPIASIH SFEL
Target Information
The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia.
t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in two infants with acute myelomonocytic leukemia have been demonstrated.
The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23.
This gene encodes 90 amino acids and is highly expressed in the thymus but not in peripheral lymphoid tissues.
In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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