Thermo Fisher Scientific CXCL17 Monoclonal Antibody (422208)
CXCL17 단백질을 인식하는 Mouse IgG2b 단일클론 항체. Western blot, ICC/IF, Flow cytometry에 적합하며 인간 시료에 반응. 단백질 A/G로 정제된 동결건조 형태로 제공되며, 재구성 후 PBS 내 0.5 mg/mL 농도로 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunocytochemistry (ICC/IF) | 8–25 µg/mL |
| Flow Cytometry (Flow) | 0.25 µg per million cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 422208 |
| Immunogen | E. coli-derived recombinant human CXCL17/VCC-1 (Leu24–Leu119) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2607196 |
Product Specific Information
- In direct ELISAs and Western blots, approximately 25% cross-reactivity with recombinant mouse CXCL17 is observed.
- Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
CXCL17 is a chemokine that acts as a chemoattractant for monocytes, macrophages, and dendritic cells. It functions as a mucosal chemokine attracting immune cells to the lungs and plays roles in angiogenesis and potential tumor development. CXCL17 also exhibits anti-inflammatory activity in the stomach and contributes to innate defense against infections. Additionally, it activates the C-X-C chemokine receptor GPR35, inducing a transient rise in intracellular calcium levels. The 4-Cys form of CXCL17 shows higher chemoattractant potency than the 6-Cys form. Dysregulation of CXCL17 has been associated with cholera.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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