Thermo Fisher Scientific Protein C Monoclonal Antibody (9072)

Applications

Tested Dilution

Publications

Western Blot (WB)

5-10 µg/mL

-

ELISA (ELISA)

5-10 µg/mL

-

Inhibition Assays (IA)

Assay-dependent

-

Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rat / IgG

Class

Monoclonal

Type

Antibody

Clone

9072

Immunogen

Mouse protein C.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

7.7 mg/mL

Purification

SDS-PAGE

Storage buffer

50% water with 50% glycerol

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2172291

Product Specific Information

MA1-43032 detects Protein C in mouse samples.

MA1-43032 has successfully been used in Western blot and ELISA applications.

MA1-43032 was derived from mouse protein C.

Target Information

Protein C is a vitamin K-dependent plasma glycoprotein that is cleaved to its activated form by the thrombin-thrombomodulin complex. Protein C in its activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Protein C is a vitamin K-dependent serine protease produced in the liver and made up of 2 polypeptide chains. The 62 kDa proenzyme is activated by thrombin bound to an endothelial surface receptor and the active enzyme cleaves factor Va and VIIIa and thus inhibits blood coagulation. The molecular weight of the active enzyme is 55 kDa and the normal concentrations in human plasma is approximately 1-3 ng/mL because of the very fast turnover, the proenzyme concentration is approximately 3 µg/mL. Mutations in the Protein C gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.