Thermo Fisher Scientific CHCHD6 Polyclonal Antibody
Rabbit polyclonal antibody targeting human CHCHD6 protein. Recognizes recombinant CHCHD6 antigen with high specificity. Suitable for mitochondrial protein research and functional studies. Provided as liquid form, unconjugated, 0.4 mg/mL concentration. ...
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Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human CHCHD6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664583 |
Product Specific Information
Immunogen sequence:
RDTFYKEQLER IERKNAEMYK LSSEQFHEAA SKMESTIKPR RVEPVCSGLQ AQILHCYRDR PHEVLLCSDL VKAYQRCVSA AHK
Highest antigen sequence identity to the following orthologs: mouse 85%, rat 85%.
Target Information
CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain.
It forms a complex with mitochondrial proteins such as mitofilin, SAM50, metaxins 1 and 2, and CHCHD3.
Knockdown of CHCHD6 causes severe defects in mitochondrial cristae morphology, reductions in cell growth, ATP production, and oxygen consumption.
This decrease also leads to reduced mitofilin protein levels, while mitofilin knockdown similarly reduces CHCHD6 levels, suggesting coordinated regulation.
CHCHD6 knockdown in human cancer cells enhances sensitivity to genotoxic anticancer drugs, indicating that CHCHD6 may be a potential therapeutic anti-tumor target.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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